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Natural Estrogen

(Manufacturer Discontinued)

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Natural Estrogen with Pomegranate Extract is one answer to the concerns of maintaining healthy hormone function. A review of
the published literature reveals some interesting findings about how plant-derived estrogens can provide safe and effective support
for such menopausal complaints as hot flashes.38-55
Derived from organically grown fruit, the pomegranate extract in this formula has the same ratio of polyphenols as you’d find in the
whole fruit and all the benefits you’d get from the juice without the sugar, calories, and additives. Punicalagins, the main
polyphenol responsible for pomegranate’s health properties, have been shown to be a powerful antioxidant.56 In fact, the health
effects from the juice and the seeds work synergistically, providing an array of health benefits.
Cruciferous vegetables (broccoli, cauliflower, brussels sprouts, etc.) are a rich source of glucosinolates and their hydrolysis
products, including indoles and isothiocyanates. Scientists have identified specific extracts from cruciferous vegetables (broccoli,
cauliflower, Brussels sprouts, etc.) that modulate hormones in a way that helps maintain healthy cell division. For instance, animal
studies have shown that the cruciferous vegetable extract indole-3-carbinol (I3C) modulates estrogen hormones by favorably
changing the ratio of protective 2-hydroxyestrone versus the damaging 16-hydroxyestrone.57 2-Hydroxyestrone has demonstrated
anti-estrogenic and anti-proliferative activity. I3C also induces phase I and II detoxifying enzymes that can help neutralize estrogen
metabolites and xenobiotic estrogen-like environmental chemicals.58 Human studies support the beneficial role of I3C and diindolyl-
methane (DIM), a compound converted by the body from I3C, in positively altering estrogen metabolism.59 I3C and DIM
have been shown to affect the proliferation of cells containing DNA damage and induce DNA repair proteins.
The glucosinolates are major constituents of cruciferous vegetables that have been shown to promote normal apoptosis and induce
the expression of the beneficial p53 gene via an estrogen-independent action.60
HMRlignan™ contains lignans, plant polyphenols which may possess antioxidant, fluid balancing, and immunomodulatory
activities.61 A naturally occurring plant lignan, 7-hydroxymatairesinol (HMR), HMRlignan™’s major component, is a precursor to
the mammalian lignan enterolactone, a human lignan found throughout the body that acts to protect the body from excess
estrogen and its unwanted effects. Enterolactone may also limit excess cell growth in specific tissues and metastasis, and has
also been linked to beneficial effects in aging women.62-67 Thus, the addition of the phytonutrient HMRlignan™ may prove
beneficial to human health.
Also included in the formula is a soy extract, SoySelect®, that significantly enhances the bioavailability of isoflavones because of
its double standardized isoflavones and Group-B Saponins. Soy flavones are phytoestrogens that weakly mimic the action of
estrogen. Soy phytoestrogens are very complex. They bind to estrogen receptors and either enhance or diminish the effects of the
This formulation of Natural Estrogen with Pomegranate Extract contains broccoli extract and HMRlignan™ in addition to
phytoestrogens and other plant extracts, all of which have proven to provide optimal female hormonal support.
Supplement Facts
Serving Size 2 caplets
Servings Per Container 30
Amount Per Serving
SoySelect® soybean (Glycine max) 70:1 Extract [standardized to 13% isoflavones (52 mg), 18% Group-B
Saponins (72 mg)]
400 mg
Broccoli (Brassica oleracea l.) Super Concentrate Extract (plant) [standardized to 4% glucosinolates (12 mg)] 300 mg
Pomella® Pomegranate (Punica granatum) Extract (fruit) [standardized to 30% Punicalagins (60 mg)] 200 mg
Black cohosh extract (Cimicifuga racemosa) (root and rhizome) [standardized to 2.5% triterpene glycosides (1
40 mg
HMRlignan™ Norway spruceP (icea abies) lignan extract (knot wood) [standardized to 90%
Hydroxymatairesinol potassium acetate complex (27 mg)]
30 mg
Dong quai extract (Angelica sinensis) (root) [std. to 1% ligustilide (.25 mg)] 25 mg
SoySelect® is a registered trademark of Indena S.p.A.
Pomella® is a trademark of Verdure Sciences, Inc.
HMRlignan™ is a trademark used under sublicense from Linnea S.A.
Licorice extract (Glycyrrhiza glabra) (root) 25 mg
Vitex extract (Vitex agnus-castus) (fruit) [std. to 5% vitexicarpin (1 mg)] 20 mg
Other ingredients: dicalcium phosphate, microcrystalline cellulose, stearic acid, croscarmellose sodium, silicon dioxide, vegetable
stearate, pharmaceutical glaze.
Contains soybeans. Contains corn.
This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), tree nuts, wheat, yeast, gluten, or
rice. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.
Dosage and Use
Take two caplets in the morning with or without food, or as recommended by your healthcare practitioner.
Natural Estrogen should be taken cyclically: three weeks on and one week off, beginning on the 5th day of the menstrual cycle
for premenopausal women, and every day for postmenopausal women.
Those taking any estrogenic product should include as part of their diet cruciferous vegetables such as broccoli, Brussels
sprouts, cabbage, and/or cauliflower.
Women should also use a natural progesterone cream when taking this product.
Consult with your physician before using this product if you are taking anti-seizure, anti-depressant or psychiatric medications, or
certain types of blood pressure (e.g. calcium channel blockers) medications. Do not take in case of pregnancy, lactation, or
estrogen-dependent tumors.



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