(VL Disco 04/18/14 ts)
Men's Hair Supplement: formula is designed to reduce hair loss associated with aging and promote a healthy scalp.*
Nufolex is a men's hair supplement designed to reduce hair loss associated with aging.* It includes ingredients thought to prevent the conversion of desirable testosterone to undesirable dihydrotestosterone (DHT).* With ingredients scientifically studied for efficacy, Nufolex is perfect for men who want to support healthy hair and a healthy scalp - without messy lotions, foams, sprays or shampoos.*
Saw palmetto berry extract and pygeum extract are well-established to promote prostate health, and they may reduce age-associated hair loss by the same mechanism.* Burdock root (Arctium lappa), considered a blood purifier, has traditionally been used to prevent hair loss associated with the normal aging process.* Ginkgo leaf is a Chinese herb that has been shown to increase blood circulation, which may support a healthy scalp and healthy hair.* Rich in minerals and antioxidants, stinging nettle root extract (Urtica dioica) and horsetail extract (Equisetum arvense) act as nourishing tonics, providing the nutrition needed to grow healthy hair.* Methylsulfonylmethane (MSM) provides the sulfur necessary for building keratin - the main structural component of hair.* Studies in animals and humans indicate pyridoxal-5'-phosphate (P5P), the active form of vitamin B6, may support hair growth.* Green tea leaf extract (Camellia sinensis) has been shown in laboratory and animal research to support healthy hair growth.* Zinc deficiency, while uncommon, can result in hair loss, and zinc supplementation may accelerate hair re-growth when levels of zinc are insufficient.*
- Reduce hair loss associated with aging*
- Support healthy hair and a healthy scalp*
- Increase circulation to the scalp*
- Provide the nutrition needed to grow healthy hair*
- Help build keratin, the main structural component of hair*
- Support hair re-growth*
Why Nufolex is Superior
- Only the best, scientifically researched ingredients used
- Pharmaceutical grade and quality
- Wide spectrum of effective compounds, as opposed to lesser formulas with just a few ingredients
- Guaranteed pure and potent
- Ingredients fully evaluated by NutraOrigin for safety and quality
- Higher dosages and potency than most brands
- Quality backed by independent inspection
- Manufactured and packaged in facilities with the Good Manufacturing Practices (GMP) clean bill of health certification, which assures the highest level of quality
|Serving Size||6 Vegetarian Capsules|
|Servings per Container||30|
|Amount per Serving||% Daily Value|
|Pyridoxal-5'-phosphate (P5P) (activated B6)||60 mg||3000%|
|Zinc (as Zinc Citrate)||15 mg||100%|
|Burdock Root (Arctium lappa)||1,000 mg||**|
|Ginkgo Extract [standardized to 24% ginkgo flavonglycosides and 6% terpene lactones] (leaf)||200 mg||**|
|Green Tea (Camellia sinensis) Extract [standardized to 98% polyphenols, 80% catechins and 70% EGCG]||800 mg||**|
|Pygeum Bark (Pygeum africanum) Extract [standardized to min. 13% sterols]||300 mg||**|
|Stinging Nettle (Urtica dioica) Extract 16:1 (root)||700 mg||**|
|Saw Palmetto (Serenoa repens) Extract [standardized to 85%-95% fatty acids and biologically active sterol compounds] (berry)||330 mg||**|
|Horsetail (Equisetum arvense) Extract [standardized to min. 8% vegetal silica]||600 mg||**|
|MSM (methyl-sulfonyl-methane)||200 mg||**|
|** Daily Value not established|
OTHER INGREDIENTS: vegetable cellulose (capsule shell), cellulose, magnesium stearate, silica.
How it works
Developed based on a thorough review of the scientific evidence, NutraOrigin's Nufolex formula includes only ingredients with documented efficacy and safety, and contains no artificial colors, flavors or preservatives. The ingredients described below will give you a better understanding of how Nufolex works to reduce hair loss associated with aging.*
Saw Palmetto Berry Extract and Pygeum Extract
Saw palmetto (Serenoa repens) and pygeum are well-established to promote prostate health, and they may reduce age-associated hair loss by the same mechanism.*
One randomized, double-blind, placebo-controlled pilot study of 19 men yielded promising results. Participants took either a saw palmetto plus beta-sitosterol supplement or a placebo. Thei hair was evaluated by an investigative staff at baseline and again four and a half months later. At the end of the study, 60% of men in the saw palmetto group were rated as "improved," compared to just 11% in the placebo group.* (1) Due to the small sample size, the results were not statistically significant, but they do establish the need for a larger clinical trial. It is believed that saw palmetto inhibits the enzyme that converts testosterone into the undesirable dihydrotestosterone.* (1)
While no human studies have been conducted to date on pygeum and hair loss due to normal aging, laboratory research has shown that the herb binds to human androgen receptors.* (2) By blocking the uptake of testosterone, pygeum could theoretically prevent its conversion to dihydrotestosterone.* However, more research is needed to confirm this theory.
Arctium lappa, also known as burdock, is a plant native to Europe and Asia. Herbalists consider burdock to be a powerful blood-purifying agent.*
Burdock root has traditionally been used to prevent hair loss associated with the normal aging process.* (3) Animal research indicates burdock supports a healthy response to inflammation, which may be important, as inflammation of the hair follicle could be a factor in age-related hair loss.* (4,5)
Ginkgo Leaf Extract
Hair loss that naturally accompanies aging may be due in part to microvascular insufficiency - i.e. a lack of circulation to the body's extremely small blood vessels, such as those in the scalp. If a root does not get enough blood, oxygen and nutrients, it may die and fall out.
Ginkgo biloba is a Chinese herb that has been shown to increase blood circulation, which may support a healthy scalp and healthy hair.* (6,7,8)
Green Tea Extract
Green Tea (Camellia sinensis) is made from the same plant as black tea; however, because it is less processed, it retains higher levels of active constituents. The main antioxidants contained within green tea are catechin polyphenols, and scientists have paid particular attention to a constituent called epigallocatechin gallate (EGCG). A recent USDA tea study noted that among all the catechins, EGCG was the most potent by a wide margin.
According to animal research, polyphenolic compounds in green tea leaf extract support healthy hair growth.* (9) A laboratory study found that EGCG promoted hair growth in human hair follicles ex vivo and stimulated the growth of dermal papilla cells in vitro.* (10) Ginkgo appears to work by inhibiting the enzyme that converts testosterone into dihydroxytestosterone.* (10)
Stinging Nettle Root Extract and Horsetail Extract
Stinging nettle (Urtica dioica) and horsetail (Equisetum arvense) have traditionally been used to reduce hair loss associated with aging and may strengthen new and existing hair.* (11,12,13)
Both herbs are valued for their high content of naturally occurring minerals and antioxidants. Nettle contains up to 20% minerals - including calcium, potassium and silicon - and is also rich in antioxidants such as flavonoids, vitamin C, beta carotene and vitamin E. Horsetail contains large amounts of silica, cysteine and sulfur, as well as flavonoids and phenolic acids. As such, these herbs act as nourishing tonics, providing the nutrition needed to grow healthy hair.*
Keratin, a strong, fibrous protein, is the main structural component of hair. It is made up of amino acids such as glycine, alanine and the sulfur-containing cysteine. Therefore, healthy hair depends on adequate amounts of sulfur.
Methylsulfonylmethane (MSM) is a sulfur-containing compound that naturally occurs in the food supply. It is used to help maintain normal keratin levels in hair, skin and nails.*
Pyridoxal-5'-phosphate (P5P) is the active form of vitamin B6. Because vitamin B6 plays a role in amino acid metabolism, it is needed for the proper growth of all parts of the body, including the hair.*
Studies in animals and humans indicate vitamin B6 may support hair growth.* (14,15) It has been shown in a laboratory model to potentiate zinc's ability to inhibit the enzyme that converts testosterone into dihydroxytestosterone.* (16) Pyridoxal-5'-phosphate (P5P) appears to be better absorbed in some individuals than the commonly used form of vitamin B6 (pyridoxine). (17)
The trace element zinc is one of the essential minerals in the human diet. Zinc deficiency, while uncommon, can result in hair loss.* (18)
In an animal model, zinc was shown to accelerate hair re-growth caused by chemically induced hair loss.* (19) A human study found that high-dose zinc therapy (200 mg, three times a day) arrested hair loss due to zinc deficiency and promoted hair re-growth.* (20) Laboratory research indicates that zinc works by limiting the conversion of testosterone into dihydroxytestosterone.* (16)
- Prager N, et al. "A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia." J Altern Complement Med. (2002) Apr;8(2):143-52.
- Shenouda NS, et al. "Phytosterol Pygeum africanum regulates prostate cancer in vitro and in vivo." Endocrine (2007) Feb;31(1):72-81.
- Natural Standard Research Collaboration. Burdock (Arctium lappa). MedlinePlus. Updated Aug. 26, 2009. http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-burdock.html
- Lin CC, et al. "Anti-inflammatory and radical scavenge effects of Arctium lappa." Am J Chin Med (1996) 24(2):127-137.
- Chittur S, Parr B, Marcovici G. "Inhibition of inflammatory gene expression in keratinocytes using a composition containing carnitine, thioctic acid and saw palmetto extract." Evid Based Complement Alternat Med. (2009) Aug 19. [Epub ahead of print]
- DeFeudis FV. Ginkgo biloba Extract (EGb 761): Pharmacological Activities and Clinical Applications. Paris, France: Elsevier Science (1991) 143-146.
- Kleijnen J, Knipschild P. "Ginkgo biloba." Lancet (1992) 340:1136-1139.
- Jung F, et al. "Effect of Ginkgo biloba on fluidity of blood and peripheral microcirculation in volunteers." Arzneimittelforschung (1990) 40:589-93.
- Esfandiari A, Kelly AP. "The effects of tea polyphenolic compounds on hair loss among rodents." J Natl Med Assoc (2005) Aug;97(8):1165-9.
- Kwon OS, et al. "Human hair growth enhancement in vitro by green tea epigallocatechin-3-gallate (EGCG)." Phytomedicine (2007) Aug;14(7-8):551-5.
- Hobbs, Christopher. Herbal Remedies for Dummies. IDG Books, Foster City CA (1998).
- American Herb Association. Complete Book of Herbs. Publications International, Ltd., IL (1997).
- Fischer-Rizzi, Susanne. Medicine of the Earth. Rudra Press, Cambridge MA (1996).
- Brzezinska-Wcislo L. "Evaluation of vitamin B6 and calcium pantothenate effectiveness on hair growth from clinical and trichographic aspects for treatment of diffuse alopecia in women." Wiad Lek (2001) 54(1-2):11-8.
- D'Agostini F, et al. "Chemoprevention of smoke-induced alopecia in mice by oral administration of L-cystine and vitamin B6." J Dermatol Sci. (2007) Jun;46(3):189-98.
- Stamatiadis D, Bulteau-Portois MC, Mowszowicz I. "Inhibition of 5 alpha-reductase activity in human skin by zinc and azalaic acid." Br J Dermat (1988) 119:627-632.
- Lieberman, Shari. The Real Vitamin & Mineral Book. Avery, New York (2007).
- Murray, Michael T. Encyclopedia of Nutritional Supplements. Prima Publishing, Roseville CA (1996).
- Plonka PM, et al. "Zinc as an ambivalent but potent modulator of murine hair growth in vivo - preliminary observations." Exp Dermatol (2005) Nov;14(11):844-53.
- Neve HJ, et al. "Reversal of hair loss following vertical gastroplasty when treated with zinc sulphate." Obes Surg (1996) Feb;6(1):63-65.