DHEA, the most abundant steroid in the blood of adult humans, peaks in early adulthood and declines with age. Animal research indicates that 7-Keto, a natural metabolite of DHEA, is a more active inducer of thermogenic enzymes than DHEA. Research on humans has shown that supplementation with 7-Keto is well tolerated. It is not converted to estrogens or androgens, a point of concern for many people.