Best 3000 GDU Bromelain (500mg) 90 Veggie Caps
Suitable for vegetarians
- Science-based nutrition
- Dietary supplement
- Supporst cardiovascular and joint wellness*
Bromelain is an enzyme derived from pineapple stem and fruit that has
proteolytic (protein-digesting) properties. The bromelain found in Best 3000 GDU
Bromelain is the most potent form of this enzyme found on the market. The 3000
GDU refers to the standardization of enzymatic potency and reflects the quality
of the raw material used in the product. Bromelain is renowned for its
digestion-enhancing characteristics and also has beneficial systemic effects
within the body.* Bromelain may also help support cardiovascular and joint
Suggested Use: As a dietary supplement, take 1 capsule 2 - 3
times daily away from food, or as directed by a physician.
Serving Size: 1 capsule
Serving per container: 90 servings
Amount Per Serving
(3,000 gelatin-digesting units (GDU)/gram)
* % Daily Value based on a diet supplying 2000 calories per day.
† Daily Value not established
Other Ingredients: Cellulose, modified cellulose (vegetarian
Contains nothing other than listed ingredients.
Does Not Contain: milk, egg, wheat, gluten, corn,
sugar, sweeteners, starch, salt, or preservatives.
Best 3000 GDU Bromelain is a proteolytic enzyme that
supports healthy immune function.*
Bromelain has the ability to activate various immune cells and their
cytokines.2 Cytokines are signaling molecules secreted by immune
cells that act as messengers to alert other immune cells. In vitro trials
have shown that bromelain can alter immune cell secretion of cytokines in a
way that would be favorable for maintaining balance in the human immune
system.3 There is also in vitro evidence that bromelain can alter T cell
signal transduction, facilitating immune cell communication, which would
also contribute to a balanced immune response in the human body.4
Bromelain’s enzymatic activity is key in these reactions, and Doctor’s Best
3000 GDU Bromelain has the highest potency per capsule.
• Best 3000 GDU Bromelain supports joint
Several clinical studies have also looked at the effects of bromelain on
the musculoskeletal system. A series of 29 case studies using 60–160 mg of
bromelain per day for 3 weeks to 3 months showed beneficial effects in
overall joint health.5
A 2002 open label human trial confirmed the ability of bromelain to support
healthy joint function. One hundred twenty-six participants were randomly
assigned to receive either 200 or 400 mg of bromelain daily for 30 days.
Individuals reported their results via questionnaires that included
indicators of joint health as well as psychological well-being. Both groups
reported significant benefits. Overall, bromelain was found to promote joint
health, while additionally showing dose-dependent improvements in feelings
of well-being and general health.6
• Best 3000 GDU Bromelain supports healthy
In several randomized, controlled clinical trials, supplementation with
bromelain was found to be supportive of respiratory health compared to
placebo.7,8,9 In one human study, 16 men and 32 women were given
either placebo or two bromelain pills, taken four times daily for six days.
The bromelain group benefited with an enhanced breathing ability and a
higher occurrence of reporting a “good” rating for the overall effect of the
supplement.8 In a similar double-blind clinical trial of 59
subjects that investigated the respiratory implications of bromelain usage,
the 29 subjects given bromelain four times daily had higher ratings of
“excellent” improvement compared to placebo.9 An animal study suggests that
the mechanism of action for the enhanced respiratory function could be
through bromelain’s influence over immune response.10
• Best 3000 GDU Bromelain supports healthy
Evidence suggests that bromelain can modulate adhesion molecules on blood
cells and the cells lining the walls of blood vessels, thereby promoting
healthy circulation. Bromelain does so through its proteolytic
activity—cleaving proteins from the surface of cells. Several important
human proteins affected include fibrin, albumin, casein, angiotensin II and
bradykinin. Fibrin and albumin are blood proteins that each provide
contributions to the maintenance of a healthy blood flow, while angiotensin
II and bradykinin play a role in the pliability of blood vessels. All of
these compounds are highly involved in complex systems that are implicated
in a healthy flow of blood and optimal cardiovascular health.1,11
While bromelain is most noted for its enzyme activity, not all of the
physiological activity of bromelain can be attributed to its protease
activity. It appears that the other compounds within bromelain act
synergistically to provide its wealth of benefits.12 Given its
wide range of activity, bromelain can be valued as a factor in healthy
maintenance of multiple systems within the human body.
* This statement has not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any
1. Taussig SJ and Batkin S. Bromelain, the enzyme complex of pineapple (ananas
comosus) and its clinical application. An update. J Ethnopharmacol.
2. Maurer, H.R., Bromelain: biochemistry, pharmacology and medical use. Cellular
and Molecular Life Sciences. 2001; 58:1234-1245.
3. Huang J., et al. Bromelain inhibits lipopolysaccharide-induced cytokine
production in human THP-1 monocytes via the removal of CD14. Immunological
Investigations. 2008; 37:263-277.
4. Secor E.R., et al. Bromelain treatment reduces CD25 expression on activated
CD4+ T cells in vitro. International Immunopharmacology. 2009; 9:340-346.
5. Brien S., et al. Bromelain as a treatment for osteoarthritis: a review of
clinical studies. Evidence-based Complementary and Alternative Medicine. 2004;
6. Walker A.F., Bromelain reduces mild acute knee pain and improves well-being
in a dose-dependent fashion in an open study of otherwise healthy adults.
Phytomedicine. 2002; 9:681-686.
7. Guo R., et al. Herbal medicines for the treatment of rhinosinusitis: A
systematic review. Otolaryngology – Head and Neck Surgery. 2006; 135:496-506.
8. Ryan, R.E. A double-blind clinical evaluation of bromelains in the treatment
of acute sinusitis. Headache. 1967; 7(1):13-17.
9. Taub, S.J. The use of bromelains in sinusitis: a double-blind clinical
evaluation. Eye, Ear, Nose & Throat Monthly. 1967; 46(3):361-365.
10. Secor, E.R., et al. Bromelain exerts anti-inflammatory effects in an
ovalbumin-induced murine model of allergic airway disease. Cellular Immunology.
11. Kumakura S, et al. Effect of bromelain on kaolin-induced inflammation in
rats. Eur J
12. Anon. Bromelain Monograph. Alternative Medicine Review. 1998; 3(4):302-305.