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Home > Health Conditions > Joint & Bone Formulas >
Best Glucosamine Sulfate contains pure glucosamine
sulfate, as confirmed by HPLC testing. Glucosamine sulfate consists of
glucosamine, an amino sugar extracted from shellfish skeletons.
"Chitin", the resilient polysaccharide that forms the structural
framework of animal shells, is a long-chain polymer consisting of many
glucosamine molecules linked together. The purified glucosamine is then
sulfated and stabilized with potassium chloride. Note: Best Glucosamine
Sulfate is sodium-free. It contains 24-26% potassium chloride.
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Supplies the body with building material for cartilage*
Cartilage, a “connective tissue,” is composed of cells (chondrocytes),
protein fibers (chiefly collagen) and clusters of complex molecules
called “proteoglycans.” A proteoglycan consists of a long protein
(polypeptide) with many side chains attached to it. (The structure of
proteoglycan looks somewhat like a test-tube brush.) The attached side
chains are polysaccharides-chiefly chondroitin sulfate and keratin
sulfate.1,2 Glucosamine is a key component of
keratin sulfate.2 Glucosamine is also a component
of hyaluronic acid, another glycosaminoglycan found in cartilage and
other connective tissues. Hyaluronic acid forms the backbone for the
proteoglycan clusters.2 Glycosaminoglycans have a
strong attraction for water. The water-holding ability of proteoglycan
clusters to hold water gives cartilage its strong, sponge-like quality.
It also allows nutrients to flow into cartilage and wastes to flow out.2
Supports Joint Structure and Function*
Glucosamine sulfate is one the most important nutritional supplements
for joint health ever developed. Glucosamine sulfate provides
significant benefits for both the structure and function of joints. Many
years of research have produced unequivocal evidence that glucosamine
sulfate normalizes cartilage metabolism, slows breakdown of cartilage,
and improves joint function.3,4,5
Glucosamine sulfate has been thoroughly researched over the last
20 years. Experimental studies and human clinical trials convincingly
demonstrate that orally consumed glucosamine sulfate improves joint
function.
In one large open trial, over 1200 people took oral glucosamine sulfate
for periods ranging from 36 to 64 days. 252 physicians participated in
this multi-center study. 95% of the subjects experienced greater joint
comfort and increased mobility. The physicians reported “good” results
in 59%, and “sufficient” results in 36%. The improvements lasted for up
to three months after the glucosamine sulfate was discontinued.4
The effectiveness of glucosamine sulfate for joint health has been shown
in double-blind, placebo-controlled research. One study compared
glucosamine sulfate to “ibuprofen,” a commonly used pain medication,
over an eight week period. During the first two weeks, better results
were seen with ibuprofen, but by the eighth week, glucosamine sulfate
produced greater improvements in pain scores.5
Provides Sulfur, the Key Structural Mineral in Cartilage*
Sulfur, one of the body’s essential structural minerals, is incorporated
into the structure of glycosaminoglycans such as chondroitin sulfate and
keratin sulfate.1,2
Why Potassium-Stabilized Glucosamine Sulfate is Preferable
In order for glucosamine sulfate to be processed for oral consumption as
a supplement, it must be stabilized with either sodium or potassium.
Either mineral works for this purpose. Potassium is preferable for
numerous reasons; many people are on sodium-restricted diets, and the
Standard American Diet tends to be high in sodium and low in potassium.
Moreover, studies have found people needing joint support to be low in
both salivary potassium and total body potassium.6,7,8
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Suggested Use: One capsule three times daily.
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1. Bland, J.H., Cooper, S.M. Osteoarthritis: A review of the cell
biology involved and evidence for reversibility. Management rationally
related to known genesis and pathophysiology. Seminars in Arthritis and
Rheumatism 1984;14(2):106-133.
2. Hardingham, T. Proteoglycans: Their structure, interactions and
molecular organization in cartilage. Biochemical Society Transactions
1981;9(6):489-97.
3. Vidal y Plana, R.R., Bizzarri, D., Rovati, A.L., “Articular cartilage
pharmacology: I. In vitro studies on glucosamine and non-steroidal
anti-inflammatory drugs,” Pharmacological Research Communications 1978;
10(6):557-569.
4. Macario , J. T., Rivera, I.C., Bignamini, A.A., ‘Oral glucosamine
sulfate in the management of arthrosis: report on a multi-center open
investigation in Portugal,’ Pharmatherpeutica 1982; 3(3):157-68.
Abstract: An open study was carried out by 252 doctors throughout
Portugal to assess the effectiveness and tolerability of oral
glucosamine sulfate in the treatment of arthrosis. Patients received 1.5
g daily in 3 divided doses over a mean period of 50 ±14 days. The
results from 1208 patients were analyzed and showed that the symptoms of
pain at rest, on standing and on exercise and limited active and passive
movements improved steadily throughout the treatment period. The
improvement lasted for a period of 6 to 12 weeks after the end of
treatment. Objective therapeutic efficacy was rated by the doctors as
‘good’ in 59% of the patients, and ‘sufficient’ in a further 36%. These
results were significantly better than those obtained with previous
treatments (except for injectable glucosamine sulfate) in the same
patients. Sex, age, localization of arthrosis, concomitant illnesses or
concomitant treatments did not influence the frequency of responders to
treatment. Oral glucosamine sulfate was fully tolerated by 86% of
patients, a significantly larger proportion than that previously
reported with other previous treatments and approached only by
injectable glucosamine. The onset of possible side-effects was
significantly related to pre-existing gastrointestinal disorders and
related treatments, and to concomitant diuretic treatment.
5. Vaz, A.L., ‘Double-blind clinical evaluation of the relative efficacy
of ibuprofen and glucosamine sulfate in the management of osteoarthrosis
of the knee in out-patients,’ Current Medical Research and Opinion 1982;
8(3):145-149.
Abstract: A double-blind trial was carried out in 40 outpatients with
unilateral osteoarthrosis of the knee to compare the efficacy and
tolerance of oral treatment with 1.5g glucosamine sulfate or 1.2g
ibuprofen daily over a period of 8 weeks. Pain scores decreased faster
during the first 2 weeks in the ibuprofen than in the glucosamine
treatment group. Although the rate of decrease was slower, the reduction
in pain scores was continued throughout the trial period in patients on
glucosamine and the difference between the two groups turned
significantly in favor of glucosamine at Week 8. No significant
differences were observed in swelling or any of the other parameters
monitored. Tolerance was satisfactory with both treatments, with only
minor complaints being reported by 2 patients on glucosamine compared
with 5 patients on ibuprofen.
6. Siamopoulou, A. et. al. Sialochemistry in juvenile chronic arthritis.
British Journal of Rheumatology 1989;28(5):383-5.
7. Syrjanen, S. et. al. Salivary and serum levels of electrolytes and
immunomarkers in edentulous healthy subjects and in those with
rheumatoid arthritis. Clinical Rheumatology 1986;5(1):49-55.
8. Sambrook, P.N., et. al. Bone turnover in early rheumatoid arthritis.
1. Biochemical and kinetic indexes. Annals of the Rheumatic Diseases
1985;44(9):575-9. |
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