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CR Mimetic Longevity Formula

By: Life Extension

UPC Code: 737870142966

Price: $29.25

 

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CR Mimetic Longevity Formula
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CR Mimetic Longevity Formula

60 vegetarian capsules

In 2003, the Life Extension Foundation® introduced a standardized extract of resveratrol, a natural compound shown to favorably alter genes implicated in the aging process—many of the same genes that respond to calorie restriction or CR. In 2009, we introduced pterostilbene, a compound whose effects were found to work in synergy with resveratrol to activate your “longevity genes.”

This year, we advanced the field even further, bringing together the 5 known calorie restriction mimetics in a single, high potency formula: resveratrol, pterostilbene, quercetin, grape seed polyphenols, and black tea extract.1-8 Now we announce the latest innovation in the science of longevity with new CR Mimetic Longevity Formula featuring fisetin. This little-known flavonoid is the sixth compound shown to simulate a similar youthful gene expression pattern as calorie restriction9—without significant dietary modification. In the most exciting development to date, this novel compound (fisetin) may also enhance the effects of resveratrol.10

Life Extension® has gone to extraordinary lengths to identify compounds that simulate calorie restriction’s ability to trigger youthful gene expression—the process by which genes transmit signals that slow certain aspects of aging. For example, previous research funded by Life Extension showed that a combination of low-dose (20 mg) resveratrol plus grape seed extract induced many of the favorable gene expression changes observed in calorie-restricted animals. A comprehensive review of the scientific literature further revealed that certain compounds found in berries, such as pterostilbene, also possess potent “longevity gene” activators that work in synergy with resveratrol.

Most abundant in strawberries, fisetin has the power to “switch on” powerful cell signaling molecules that support youthful gene expression, DNA protection, and healthy cellular function.9 It also supports aging neurons in the presence of oxidative stress.11-13 Each serving of the new CR Mimetic Longevity Formula contains fisetin in an amount equivalent to 2 cups of strawberries, helping to further emulate calorie restriction’s favorable influence on your longevity genes. Most importantly, fisetin works in synergy with resveratrol. Researchers have uncovered compelling evidence of fisetin’s ability to stabilize resveratrol by shielding it from metabolic breakdown10 and extending its effects.

This new formula provides cutting-edge broad spectrum support for youthful gene expression from the most scientifically validated, natural sources.

References
1. Cell. 2006 Dec 15;127(6):1109-22.
2. Endocrinology. 2008 Jan;149(1):84-92.
3. Food Chem Toxicol. 2008 Apr;46(4):1320-6
4. Mol Nutr Food Res. 2008 Jun;52 Suppl 1:S62-70.
5. Cytokine. 2009 Aug;47(2):137-42
6. Nutr Cancer. 1999;35(1):80-6.
7. Anticancer Agents Med Chem. 2006 Sep;6(5):389-406.
8. Nature. 2006 Nov 16;444(7117):337-42.
9. Nature. 2004 Aug 5;430(7000):686-9.
10. Xenobiotica. 2000 Sep;30(9):857-66
11. Genes Nutr. 2009 Sep 10.
12. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16568-73.
13. Brain Res. 2007 Oct 10;1173:117-25.
Supplement Facts

Serving size 2 vegetarian capsules

Servings per container 30

Amount per serving

Trans-Resveratrol [from Polygonum cuspidatum extract (root)]

250 mg

Trans-Pterostilbene (as pure Pterospan™ and SMART™† pterostilbene)

3 mg

Quercetin (as quercetin dihydrate)

150 mg

Masquelier’s® Original OPCs [single and condensed (2-5) units of flavanols & polyphenols from Vitis vinifera (grape) seeds]

50 mg

Black tea decaffeinated (Camellia sinensis) extract (leaf) [standardized to 12% TF2a theaflavin fraction (36 mg), along with TF1, TF2b and TF3 theaflavin fractions]

300 mg

Fisetin [from (Rhus succedanea L.) extract (stem)]

48 mg

Other ingredients: vegetable cellulose (capsule), stearic acid, silica.

This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, corn or rice. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.

† Same material as research trials.
Pterospan™ (Pure Pterostilbene) and SMART™ are trademarks of Pharma Science Nutrients, Inc., and are used here under license. All rights reserved worldwide.
MASQUELIER’s® is a registered trademark of International Nutrition Company BV (INC), Loosdrecht, The Netherlands.

Dosage and Use

Take two capsules daily with or without food, or as recommended by a healthcare practitioner.

Can be taken together or in divided doses.

Caution

Consult with your doctor before using this product if you have a bleeding disorder, or if you are taking anticoagulant, antiplatelet, or diabetic medications.

Warnings
  • Keep out of reach of children.
  • Do not exceed recommended dose.
  • Do not purchase if outer seal is broken or damaged.
  • If you have a bad reaction to product discontinue use immediately.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.






Disclaimer:   This website is for informational purposes only. Always check the actual product label in your possession for the most accurate ingredient information due to product changes or upgrades that may not yet be reflected on our web site. These statements made in this website have not been evaluated by the Food and Drug Administration. The products offered are not intended to diagnose, treat, cure, or prevent any disease. If you believe that you may have a disease condition, please consult your healthcare practitioner immediately, and before using any dietary supplement product.

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