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Celadrin® is a unique formulation of esterified
(stable) fatty acids that has been shown to reduce certain effects
related to pronounced inflammatory processes that can occur in the
body. Being a complex molecule consisting of various fatty acids, it
is able to penetrate cell membranes, which enhances membrane
permeability and cell-to-cell signaling. In doing so, Celadrin® may
reduce the level of inflammatory components of the immune system
from binding to cells and thus causing occasional inflammation in
different parts of the body.1
Topical Celadrin Cream
Celadrin Cream can also be an
effective option for topical joint pain relief. Celadrin fatty acid
esters combined with 1.25% USP grade natural menthol provides minor pain
relief for sore muscles and joints and the surrounding areas. When
applied topically, Celadrin is well-absorbed and can act locally to help
maintain joint comfort and increase the range of motion of joints.
Studies have confirmed the
benefits of topical applications of the cream directly to sore joints.
In a double-blind placebo-controlled trial published in the Journal of
Rheumatology in 2004, forty individual with sore knee joints
participated.Twenty patients were given Celadrin Cream and 20 others
were assigned a placebo cream to be applied topically twice daily for 30
days. Participants were assessed on various orthopedic measures of
improvement. At the end of the study, the researchers noted that the
Celadrin Cream was an effective treatment for improving knee ROM,
ability to ascend/descend stairs, ability to rise from sitting, walk and
sit down, and unilateral balance. No changes were seen in the placebo
A second study was conducted by
the same group of researchers using a cream consisting of Celadrin and
menthol. In this trial, participants who had significant functional
performance deficiencies of elbow, knee or wrist joints were given the
cream and asked to apply it twice daily for one week.
Measure of comfort and performance
we reassessed before the treatment and again after one week. The
researchers found significant improvement with the use of the cream.
Overall, there was a significant improvement in joint range of motion,
comfort levels, muscular endurance and joint function. Even in the
relatively short period of this trial (only 1 week), the cream was
deemed to be effective for enhancing joint function in these
1. Hesslink R Jr., et al. Cetylated fatty acids
improve knee function in patients with osteoarthritis. J
2. Anonymous. Monograph: Glucosamine sulfate. Alt Med Review
3. Kraemer WJ, et al. Effect of a cetylated fatty acid topical cream
on functional mobility and quality of life of patients with
osteoarthritis. J Rheumatology 2004;4:767-74.
4. Crolle G, D'Este E. Glucosamine sulphate for the management of
arthrosis: a controlled clinical evaluation. Curr Med Res Opin
5. Rovati LC. Clinical research in osteoarthritis: design and
results of short-term and long-term trials with disease modifying
drugs. Int J Tissue React 1992;14:243-51.
Acting as a biochemical "super-thiamin," it does this through
several different cellular mechanisms, as discussed below.
6. Bassleer C, et al. Stimulation of proteoglycan production by
glucosamine sulfate in chondrocytes isolated from human
osteoarthritic articular cartilage in vitro. Osteoarthritis and
Cartilage 1998;6:427-434. Med. 2002 Oct 14;162(18):2113-23.
7. Reginster JY, et al. Long-term effects of glucosamine sulphate on
osteoarthritis progression: a randomized, placebo-controlled
clinical trial. Lancet 2001;357:251-56.
8. Macario, J. T., Rivera, I.C. Bignamini, A.A.
Oral glucosamine sulphate in the management of arthrosis: report on
a multi-centre open investigation in Portugal. Pharmatherpeutica
9. Kraemer WJ, et al. Effect of acetylated fatty
acid topical cream on functional mobility and quality of life of
patients with osteoarthritis. J Rheumatol.2004 Apr;31(4):767-74.
10. Kraemer WJ,et al. Acetylated fatty acid
topical cream with menthol reduces pain and improves functional
performance in individuals with arthritis. J Strength Cond Res.2005