Celadrin, a blend of special fatty acids is one of the most effective, natural anti-inflammatory products available. Both humans and animals have shown remarkable benefits of reduced pain and swelling, increased movement and reduction of inflammatory factors when using Celadrin. The esterified (meaning it is stable and does not react with oxygen) fatty acids present in Celadrin have pronounced anti-inflammatory effects, such as the inhibition of the endothelial cells (thin cells that line the inside of some body cavities) and decreasing the pro-inflammatory effects of other fatty acids. Celadrin works similarly to, but much more dramatically than the essential fatty acids, EPA and DHA from fish oils. Fatty acids provide many vital beneficial effects for the immune and inflammatory responses of the body. Various fatty acids induce changes in cell membranes and the responsiveness of the membrane to certain immune factors. They also play a role in suppressing inflammatory cell functions, decreasing cartilage breakdown, triggering of cell death and, like NSAIDS reducing the inflammatory activities of the COX-2 enzyme. But unlike NSAIDS there are no reported adverse effects with Celadrin.