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Home > Health Conditions > Arthritis Formulas >
| Celadrin® is a unique formulation of esterified (stable)
fatty acids that has been shown to reduce certain effects related to
pronounced inflammatory processes that can occur in the body. Being a
complex molecule consisting of various fatty acids, it is able to
penetrate cell membranes, which enhances membrane permeability and
cell-to-cell signaling. In doing so, Celadrin® may reduce the level of
inflammatory components of the immune system from binding to cells and
thus causing occasional inflammation in different parts of the body.1
Glucosamine Sulfate
Glucosamine sulfate is the most completely studied form of
glucosamine. It is commonly derived from the exoskeleton of shellfish
and is a critical nutrient needed for the synthesis and repair of joint
cartilage. Glucosamine sulfate has the ability to stimulate the
synthesis of glycosaminoglycans and other components of the structural
matrix of joint tissue. Because of the comprehensive nature of
glucosamine sulfate's effects, it may play a role in maintaining the
health of joint tissues.2
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Increased Range of Motion in Joints*
Research has shown that Celadrin® can have an impact on improving the
range of motion in the joints. A placebo-controlled trial conducted in
2002 showed that those individuals taking a complex containing Celadrin®
for 2 months had a significant improvement in knee flexion (ability to
bend the knee) over those taking a placebo.1
Another study conducted on Celadrin® published in 2004 concluded that
treatment "significantly increased physical performance (as measured by
a variety of orthopedic tests)" in patients with compromised knee
mobility. The study found that the subjects given Celadrin® showed
improvement in their ability to climb stairs, rise from a chair and
walk, along with an improved sense of balance, strength and endurance.3
Helps Maintain Healthy Joint Cartilage*
Glucosamine sulfate plays a fundamental role as a building block for
joint cartilage. Evidence to date suggests it may reduce the severity of
the symptoms in individuals with joint problems.4,5
Glucosamine sulfate has been shown in some studies to stimulate the
regeneration of damaged cartilage, while also having anti-inflammatory
effects. Research has found that glucosamine sulfate may have a
stimulatory effect on proteoglycan production from human cartilage
cells.6
A specific 3-year placebo-controlled, randomized study was conducted
to assess the impact of taking oral glucosamine sulfate on the
progression of joint space narrowing. Joint space narrowing may be
associated with certain degenerative conditions of articular tissue. The
study found that those individuals taking the oral glucosamine at the
recommended intake had no space narrowing on average over the time
period versus significant space narrowing in the placebo group.7
Glucosamine sulfate may further play a role in enhancing joint
lubrication by acting to form the protective agent mucin, a necessary
component of healthy joints.2
Maintains Joint Comfort*
The anti-inflammatory actions of Celadrin® have been demonstrated by
one double-blind, placebo controlled trial that showed Celadrin®, when
taken orally at recommended intake levels, decreased pain scores and
increased walking distance compared to the group receiving placebo. The
authors theorize that Celadrin® may work by down-regulating the effect
of certain precursors of the body's inflammatory response.1
In one large open trial, over 1200 people took oral glucosamine sulfate
for periods ranging from 36 to 64 days. Over 252 physicians participated
in this multicenter study. 95% of the subjects experienced greater joint
comfort and increased mobility. The physicians reported "good" results
in 59%, and "sufficient" results in 36%. The improvements lasted for up
to three months after the glucosamine sulfate was discontinued.8
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Suggested Adult Use: Take one tablet three times daily. Take without
food.
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1.Hesslink R Jr., et al. Cetylated fatty acids improve knee function in
patients with osteoarthritis. J Rheumatology 2002;8:1708-1712.
2.Anonymous. Monograph: Glucosamine sulfate. Alt Med Review
1999;4:3;193-195.
3.Kraemer WJ, et al. Effect of a cetylated fatty acid topical cream on
functional mobility and quality of life of patients with osteoarthritis.
J Rheumatology 2004;4:767-74.
4.Crolle G, D'Este E. Glucosamine sulphate for the management of
arthrosis: a controlled clinical evaluation. Curr Med Res Opin
1980;7:104-109.
5.Rovati LC. Clinical research in osteoarthritis: design and results of
short-term and long-term trials with disease modifying drugs. Int J
Tissue React 1992;14:243-51.
Acting as a biochemical "super-thiamin," it does this through several
different cellular mechanisms, as discussed below.
6.Bassleer C, et al. Stimulation of proteoglycan production by
glucosamine sulfate in chondrocytes isolated from human osteoarthritic
articular cartilage in vitro. Osteoarthritis and Cartilage
1998;6:427-434.
Med. 2002 Oct 14;162(18):2113-23.
8.Macario , J. T., Rivera, I.C. Bignamini, A.A. Oral glucosamine
sulphate in the management of arthrosis: report on a multi-centre open
investigation in Portugal . Pharmatherpeutica 1982; 3(3):157-68. |
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