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Omega-6 fatty acids are well-supplied in the diet by meat and vegetable oils. However, not all omega-6 fatty acids are of equal
value. Linoleic acid (not to be confused with ALA, which is in the omega-3 family) and arachidonic acid (AA) tend to be unhealthy
because they are the precursor of inflammatory eicosanoids, such as prostaglandin E2 (PGE2), thromboxane A2, and leukotriene
B4, which promote inflammation. In contrast, gamma linolenic acid (GLA), found in evening primrose oil, borage oil, and black
currant oil, is an important fatty acid that plays a beneficial role in healthy prostaglandin formation.59 Health conscious people
have been consuming a lot of borage oil to obtain GLA, the parent of the biologically active DGLA (di-homo-gamma-linolenic acid).
Life Extension’s Mega GLA provides 285 mg of GLA plus 10 milligrams of sesame lignans. These sesame lignans increase
beneficial DGLA, and they also help reduce the production of proinflammatory arachidonic acid, which is responsible for the
formation of destructive prostaglandin E2 and leukotriene B4.60 Numerous studies have documented GLAs multiple health effects,
but information about the ability of sesame to prevent the conversion of GLA into arachidonic acid indicates that many more people
may now be able to benefit from supplementing with GLA.61
Serving Size 1 softgel
Servings Per Container 60
Amount Per Serving
Calories from fat 12
Total Fat 1.3 g
Saturated fat 0.25 g
Monounsaturated fat 0.25 g
Polyunsaturated fat 0.8 g
Borage seed oil (Borago officinalis) supplying 285 mg gamma-linolenic acid (GLA) 1300 mg
Sesame seed (Sesamum indicum) lignan extract 10 mg
Other ingredients: gelatin, glycerin, water, silica, soy lecithin, carob.
Contains soybeans. Contains sesame.
This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster crab, shrimp), tree nuts, wheat, yeast, gluten,
corn, or rice. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.
Dosage and Use
Take one softgel one to two times daily with food, or as recommended by a healthcare practitioner.
Up to five softgels can be taken daily.
Do not take with fiber supplements.
Those taking anticoagulant drugs like Coumadin® (warfarin) should inform their doctor that they are taking GLA, EPA, or DHA
supplements, as the physician may want to adjust the dose of anticoagulant medication based on tests that measure coagulation
factors such as template bleeding time.
Since GLA, EPA, and DHA interfere with blood clotting, those who suffer from any type of hemorrhagic disease related to
excessive bleeding or blood vessel leakage should consult their physician before supplementing these fatty acids.
This product should not be used by individuals who have an allergy to sesame.