PureWay-C® Sustained Release
Vitamin C contains PureWay-C®, a newly discovered form of vitamin C consisting
of highly absorbable vitamin C-lipid metabolites. Vitamin C-lipid metabolites
have faster and more beneficial effects than other forms of vitamin C .
PureWay-C® Sustained Release Vitamin C also contains citrus bioflavonoids and
ascorbyl palmitate. Ascorbyl palmitate is a
fat-soluble form of vitamin C that is able to be stored in lipid cell membranes
for later use. Citrus bioflavonoids include the flavonones, such as hesperidin
and naringin, as well as the polymethoxylated flavones, such as tangeretin and
nobiletin. Bioflavonoids, and citrus bioflavonoids in particular, work in
conjunction with vitamin C to improve absorption and boost its effects
The PureWay-C® formulation
allows for better cellular uptake and absorption of vitamin C.* This enhances
the opportunity for vitamin C to take part in its wide range of support for the
human body.* Vitamin C is the main water-soluble nutrient antioxidant in human
plasma and has many functions. It is a potent free radical scavenger, immune
enhancer, and cell protector.* It maintains collagen, helps form red blood
cells, aids in the absorption of iron, stimulates adrenal function, and helps
detoxify certain metals and drugs. It also plays a role in the synthesis of
mood-enhancing neurotransmitters, in cholesterol metabolism, and in mediating
inflammation.* Citrus bioflavonoids are also
antioxidants with their own powerful biological effects including modulation of
the immune system, anti-inflammatory activity, and protection of the nervous
Contains Vitamin C-lipid Metabolites (PureWay-C®):
is a novel vitamin C preparation containing vitamin
C-lipid metabolites. Studies in the laboratory show that human cells
absorb this new form of vitamin C more rapidly and
in greater amounts than the three most popular forms of vitamin C:
ascorbic acid, calcium ascorbate and calcium ascorbate-calcium
vitro) research also shows that
Protects the nervous
system by promoting the survival of nerve cells *
Protects the immune system against damage induced by pesticides *
antioxidant and free radical scavenging activity *
Enhances normal wound
healing by improving the functioning of collagen-secreting fibroblast cells
studies conducted with
better absorbed and retained in the serum at higher levels.*
decreases blood levels of a common marker of an imbalanced immune response.*
PureWay-C® decreases blood
levels of a common marker of oxidative stress (cellular degeneration
resulting from free radical production).*
Delivers Effective Antioxidant and Free Radical Scavenging
Activity to Decrease Markers of Oxidative Stress*
vitamin C-lipid metabolite formulation has potent antioxidant and free radical
scavenging capabilities based on ORAC and DPPH assays, two methods commonly used
to evaluate antioxidant capacities. PureWay-C® reached 93% scavenging capability
using the DPPH assay, indicative of an excellent free radical scavenger.
PureWay-C® has 1343 units of antioxidant activity per gram based on ORAC analysis (ORAC
values are in ìM Trolox® Equivalents/gram of substance), showing stronger
antioxidant activity on a gram basis than some other common natural sources of
antioxidants such as green and black teas (235-1526 ORAC units), cinnamon
(1243), and broccoli (65.8-121.6)
In order for
vitamin C to exert its antioxidant benefits, it must be able to get inside
cells. PureWay-C® was tested for its ability to be taken up and retained in the
cell, and for the rate at which it is able to do so. Compared to ascorbic acid,
the most common form of vitamin C, PureWay-C® showed a 233% increase in cellular
uptake into human T-lymphocytes at both 30 and 45 minutes. This absorption level
was a 122% improvement over the next best form of vitamin C,
threonate-dehydroascorbate. The absorbed levels
peaked at approximately two hours with the cellular level of PureWay-C® at 50
nmol / mg
In order to
assess absorption in humans, PureWay-C® serum levels were measured in healthy
volunteers after oral supplementation. Forty volunteers maintained a low vitamin
C diet for 14 days and, following an overnight fast, received a single oral dose
of 1000 mg of either ascorbic acid, calcium ascorbate, PureWay-C®, or calcium
ascorbate-calcium threonate-dehydroascorbate. Blood samples were collected
immediately prior to the oral dose administration and at various times after
ingestion. Serum vitamin C levels were measured, and PureWay-C® supplementation
led to the highest absolute serum vitamin C levels when compared to the other
forms of vitamin C. At two hours, PureWay-C® levels were statistically
significantly higher than ascorbic acid and calcium ascorbate. At 24 hours post
treatment, PureWay-C® maintained the highest serum levels of vitamin C .
Supports the Body's Immune System*
chronic, or unbalanced immune activation is associated with a variety of health
problems. High levels of certain proteins in the blood serve as indicators of
this unhealthy condition. Levels of vitamin C in the blood have been found to be
inversely associated with these protein markers of unbalanced immune activation
research has attributed much of the beneficial immune-related effects of vitamin
C supplementation to the reduction of circulating levels of these markers .
To test the effects of vitamin C on levels of these markers in humans, forty
volunteers maintained a low vitamin C diet for 14 days and, following an
overnight fast, received a single oral dose of 1000 mg of either ascorbic acid,
calcium ascorbate, PureWay-C®, or calcium ascorbate-calcium
threonate-dehydroascorbate. Blood samples were collected immediately prior to
the oral dose administration and at various times after ingestion. Plasma levels
of two markers of unbalanced immune activation were measured by enzyme linked
immunosorbent assay (ELISA). Oral supplementation with PureWay-C® led to greater
reductions in plasma levels of these markers compared to the other vitamin C
resulted in greater and more beneficial effects than what was observed with the
other forms of vitamin C
Laboratory testing also indicates PureWay-C® has a greater protective effect on
immune cells that have been exposed to toxins and pesticides.* PureWay-C® is
more active and effective than ascorbic acid, calcium ascorbate and other
popular forms of vitamin C in reducing hyperactivity of white blood cells and
inflammatory damage caused by substances that are foreign to the body.* Human
T-lymphocytes are white blood cells that aggregate or clump together when
exposed in the laboratory to toxins such as the common pesticide bifenthrin or
the toxin phytohemagglutinin (PHA). These immune cells were treated
in vitro with bifenthrin and PHA, and then either given no further
treatments or treated further with PureWay-C® or other popular ascorbate brands.
The cells were then incubated and the number of cells per aggregate was
determined. PureWay-C® reduced PHA-induced T-cell aggregation, a marker of
inflammatory hyperactivation, more than other popular forms of vitamin C .
When these immune cells were treated with the pesticide bifenthrin, along with
various formulations of vitamin C, all of the vitamin C formulations reduced the
pesticide-mediated aggregation. However, the effect of PureWay-C® on inhibiting
the aggregation was at least double the effect of the next best vitamin C
bioflavonoids also possess a wide range of immune and inflammation- related
therapeutic properties . Immune and inflammation responses are controlled by
enzymes and cytokines produced in the body such as TNF-alpha, a pro-inflammatory
cytokine. Citrus bioflavonoids can inhibit these enzymes and cytokines to
decrease inflammatory responses in vitro . In
vitro studies also indicate how bioflavonoids modulate inflammation through
a number of other mechanisms, such as inhibition of gene expression in the cells
lining blood and lymph vessels . In these ways, bioflavonoids may support
overall immune health and wellness.
Supports a Healthy Cardiovascular System*
prospective studies assessing vitamin C intake in large numbers of people who
are followed over time indicate that the highest intakes of vitamin C are
associated with enhanced cardiovascular benefits. In addition, some large
studies in healthy individuals who take vitamin C supplements suggest that
vitamin C supplements support normal heart function. The Nurses' Health Study of
more than 85,000 women followed for over 16 years found vitamin C intakes of
more than 359 mg per day from diet plus supplements or from supplements alone
were associated with a 27-28% reduction in cardiovascular risk factors . In a
recent review of studies in which more than 290,000 healthy adults were followed
for an average of 10 years, those who took more than 700 mg per day of
supplemental vitamin C had a substantially better cardiovascular profile than
those who did not take vitamin C supplements .
One of the ways
vitamin C may enhance cardiovascular health is by supporting levels of good
cholesterol (HDL) that are already within the normal range. Researchers from the
National Institute on Aging and the USDA investigated the effect of vitamin C
intake on lipid metabolism . After adjustment for age, sex, obesity, and
smoking, they found that in healthy adults with adequate vitamin C intake there
was a significant positive association between high levels of plasma vitamin C
and healthy lipid ratios. The research suggested that higher concentrations of
vitamin C in the blood, the result of taking up to two to three times the RDA,
are associated with improved cardiovascular health.
and animal studies suggest that citrus bioflavonoids also support healthy
cardiovascular function and circulation . An analysis of the flavonoid
intake of 34,489 postmenopausal women in the sixteen-year Iowa Women's Health
Study found significant positive correlations between flavonone and flavone
intake and cardiovascular function . These two categories of flavonoids,
flavonones and flavones, are the primary flavonoids found in citrus fruit.
Hypothesized mechanisms by which flavonoids may have cardioprotective effects
include antioxidant protection of lipid molecules, anti-inflammatory action,
improvement in endothelial function, and enhancement of circulation [14, 15].
Protects the Body's Nervous System*
Vitamin C is
thought to protect the nervous system from degeneration. In order for nerve
cells to survive, the body secretes a critical protein called nerve growth
factor (NGF). In the laboratory, vitamin C formulations enhance the NGF-mediated
growth of nerve cells. In vitro research indicates that compared
to other forms of vitamin C, PureWay-C® is more beneficial to the nervous
system. Nerve cells were treated with 100 ng/ml of NGF, and incubated for a
24-hour period. These cells then received either no further treatment, or
treatment with 0.5 ìM of ascorbic acid, calcium ascorbate, PureWay-C® or other
ascorbate brands. After these treatments, the cells were incubated over another
24-hour period during which the formation of developing nerve cells was assessed
at hours 1, 3, 6, 9, 12 and 24. Compared with the other forms of vitamin C,
PureWay-C® significantly increased the formation of developing nerve cells .
bioflavonoids have also demonstrated neuroprotective effects in laboratory and
animal models. Hesperidin, for instance, has the ability to cross the blood
brain barrier and act on the central nervous system . Hesperidin and related
citrus bioflavonoids protect nerve cells against oxidative damage in
vitro . Even at physiological concentrations, these flavonoids
significantly protected cells of the nervous system from hydrogen
peroxide-induced oxidative damage. Hydrogen peroxide is formed in the brain
under certain conditions, and quickly converts to highly toxic hydroxy radicals
that damage nerve cells.
Suggested Adult Use: For continuous 24 hour Vitamin C
coverage take one tablet every 12 hours.
Does Not Contain: milk, egg, wheat, corn, sugar, sweeteners, starch,
salt, or preservatives.
B.S. and P.P. Perez, Absorption rates and free radical scavenging
values of vitamin C-lipid metabolites in human lymphoblastic cells. Med Sci
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J.A. and P. Bose, Comparative bioavailability to humans of ascorbic
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D., C. Vazquez, and M. Fletcher, Vitamin C-lipid metabolites:
Uptake and Retention and Effect on Plasma C-Reactive Protein and Oxidized
LDL Levels in Healthy Volunteers. 2007, Comprehensive HealthCare of Miami,
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B.S. and P.P. Perez, A novel vitamin C preparation enhances neurite
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hyperactivation. Med Sci Monit, 2007. 13(3): p. BR51-8.
J.A., K. Grohmann, and N. Guthrie, Biological properties of citrus
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S.K., et al., Vitamin C and risk of coronary heart disease in women.
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P.J., et al., Flavonoid intake and cardiovascular disease mortality:
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D.J., et al., Comparison of the antioxidant effects of Concord grape
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