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Home > Supplements > Antioxidants >
Gugulipid®
Gugulipid® is the leading extract of gum guggul resin. Gum guggul is
harvested from Commiphora mukul, a shrub-like tree indigenous to arid
regions of northern India.
Gum Guggul
Gum guggul is related to myrrh gum and also to Boswellia serrata,
another resinous herb prominent in the Ayurvedic materia medica. Gum
guggul, often referred to simply as “guggul,” has been used in the
Ayurvedic herbal tradition since at least 600 B.C. The herb is mentioned
in the Vedas, the Holy Scriptures of India, which are estimated to date
back anywhere from 3,000 to 10,000 years.1
Modern investigation into gum guggul began in 1964, with a series
of tests conducted by G.V. Satyavati.2 The
inspiration for this research is a Ayurvedic treatise written in
Sanskrit that describes in detail a condition called “coating and
obstruction of channels.” Impressed by the apparent analogy to the
cardiovascular system, Satyavati and others initiated a series of tests
to determine if gum guggul, which was mentioned in the treatise, would
have any effect on blood lipid levels. This set the stage for an
extensive series of studies on gum guggul’s pharmacology and clinical
effects.
Guggulsterones
Systematic analysis of gum guggul resin carried out by Indian
researchers in the 1980s identified the active ingredients as a group of
lipid-based compounds called guggulsterols and guggulsterones. It was
determined that two members of this group, Z-guggulsterone and
E-guggulsterone, are largely responsible for the herb’s effect on
cholesterol and blood fats.1,3 An extract
standardized for guggulsterone content of gum guggul was then developed
by the CDRI in Lucknow, India. This extract, called “Gugulipid®,” is now
the preferred form of gum guggul for use in clinical studies.2
Ultra Guggulow contains Gugulipid® standardized to supply 25 mg of
guggulsterones per 1000 mg of extract.
Bioperine®
Traditional Ayurvedic herbal formulas often include black pepper and
long pepper as synergistic herbs. The active ingredient in both black
pepper and long pepper is piperine, an alkaloid. Experiments carried out
to evaluate the scientific basis for the use of peppers have shown that
piperine significantly enhances bioavailability when consumed with other
substances.4
Bioperine® contains 95% piperine extracted from the fruits of
black pepper. Several double-blind clinical studies have confirmed that
Bioperine® increases absorption of nutrients.5
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Helps Maintain Normal Healthy Cholesterol Levels*
The research of gum guggul over the last 30 years has produced a wealth
of evidence establishing this herb’s beneficial effect on cholesterol
and blood fats. The preliminary studies carried out by Satyavati and her
colleagues were done on rabbits fed hydrogenated vegetable oil to
artificially elevate cholesterol levels. In contrast to non-treated test
subjects, rabbits given gum guggul had normal cholesterol and blood
lipid levels and healthy blood vessels.2
A number of multicentric clinical trials have tested the efficacy
of Gugulipid® for maintaining normal cholesterol.6
The CDRI has conducted Phase 1 trials to establish the safety of the
extract. Gugulipid® has been found safe and free of unwanted effects on
blood chemistry, liver function and the heart.7
Phase II trials confirmed Gugulipid®’s effectiveness in normalizing
total cholesterol, LDL, HDL and triglycerides.7,8
SOD-Protecting, Antioxidant Action*
In an animal study carried out by the CDRI, guggulsterones reversed the
decrease in SOD (superoxide dismutase) activity that results from
reduced blood flow to the heart.9 The researchers
reported that “SOD was significantly protected by guggulsterone.”9
Increases in lipid peroxides (free-radical byproducts) and xanthine
oxidase, an enzyme that produces oxygen free radicals, were also
reversed. Although preliminary, these findings lend additional support
to the use of Gugulipid® for sustaining cardiovascular health.
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Suggested Use: 2 to 3 tablets daily, taken with food. Begin by taking 1
per day for the first seven days, followed by 2 per day for the next
seven days, then increase to full desired intake.
The black pepper fruit extract in this product is Bioperine, a
patented standardized extract containing 95% piperine.
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1. Satyavati, G., “Gugulipid®: a promising hypolipidaemic agent from gum
guggul (Commiphora wightii).” Economic and Medicinal Plant Research
1991;5:47-82.
2. Satyavati, G., “Gum guggul (Commiphora mukul) — The success story of
an ancient insight leading to a modern discovery.” Indian J. Med. Res.
1988;87:327-335.
3. Dev, S., “A modern look at an age-old Ayurvedic drug-guggulu.”
Science Age 1987; July:13-18.
4. Atal, C.K., Zutshi, U., Rao, P.G., “Scientific evidence on the role
of Ayurvedic herbals on bioavailability of drugs.” J. of
Ethnopharmacology 1981;4:229-32.
5. “Bioperine® — Nature’s Bioavailability-Enhancing Thermonutrient.
Executive Summary.” 1996; Sabinsa Corporation, Piscataway, N.J.
6. Nityanand, S., Srivastava, J.S., Asthana, O.P., “Clinical trials with
Gugulipid®.” J. Ass. Physicians of India 1989; 37(5):323-28.
7. Agarwal, R.C. et. al., “Clinical trial of Gugulipid® — a new
hypolipidemic agent of plant origin in primary hyperlipidemia.” Indian
J. Med. Res. 1986;84:626-34.
8. “Gugulipid®,” Drugs of the Future 1988;13(7):618-619.
9. Kaul, S., Kapoo, N.K., “Reversal of changes of lipid peroxide,
xanthine oxidase and superoxide dismutase by cardio-protective drugs in
isoproterenol induced myocardial necrosis in rats.” Ind J. Exp. Biol.
1989; 27:625-27. |
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