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Home > Health Conditions > Prostate Formulas >
Saw Palmetto Extract
Standardized Saw palmetto berry extract, guaranteed to contain 90
percent fatty acids and sterols.
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Effective Prostate Support
Saw palmetto extract is one of the world's leading herbal products for
prostate support. Widely-cited clinical studies conducted over the last
fifteen years have clearly established the ability of Saw palmetto
extract to produce major improvements in prostate-related urinary
function. Saw Palmetto's key active ingredients help to normalize
prostate gland structure.
Discussion
As men pass through and beyond middle age, hormonal changes occur which
can impact the prostate gland. Levels of dihydrotestoterone (DHT), a
normal metabolite of testosterone, increase. This, plus an increased
binding of DHT to nuclear receptors in the prostate cell, results in
growth of prostate tissue. This tissue growth takes place in the part of
the prostate which surrounds the urethra, the tube for urine excretion.
This can constrict the urethra, resulting in urinary disturbances.
Saw palmetto extract has been shown to inhibit 5 alpha-reductase, an
enzyme that controls conversion of testosterone to DHT. Saw palmetto
extract also blocks the binding of DHT to prostate cells. These
mechanisms are believed to account for Saw palmetto extract's positive
effect on prostate gland structure.
In clinical studies, Saw palmetto extract has produced measurable
improvements in urinary functions and prostate size. Quality of life
scores have also improved.
The results with Saw palmetto extract have been duplicated in open
trials and controlled, double-blind studies.
Saw palmetto extract is safe and virtually free of side-effects.
Saw palmetto’s effectiveness comes from its content of natural fatty
acids and sterols. These include oleic acid, lauric acid, campasterol,
stigmasterol, beta-sitosterol and others. The standard of quality for
Saw palmetto extract products is a high concentration of fatty acids and
sterols, equaling 90%.
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Suggested Adult Use: One to capsule daily with food.
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1. Braeckman, J., 'The extract of Serenoa repens in the treatment of
benign prostatic hyperplasia: a multicenter open study,' Current
Therapeutic Research 1994: 55(7):776-85.
Abstract
Because prostatic surgery is not the treatment of choice for most
patients with benign prostatic hyperplasia (BPH), the therapeutic effect
of a 160 mg, twice daily, oral dose of Serenoa repens extract was
studied during a 3-month open trial in 505 patients with mild to
moderate symptoms of BPH. The efficacy of the regimen was evaluated in
305 of these patients. Traditional parameters for quantifying prostatism,
such as the International Prostate Symptom Score, the quality of life
score, urinary flow rates, residual urinary volume, and prostate size,
were found to be significantly improved after only 45 days of treatment.
After 90 days of treatment, a majority of patients (88%) and treating
physicians (88%) considered the therapy effective. In addition, the
serum prostate-specific antigen concentration was not modified by the
drug, thus limiting the risk of masking any possible development of
prostate cancer during treatment. The incidence of side effects (5%) was
low and compares favorably with that reported for existing therapies
used in BPH patients. The extract of Serenoa repens appears to be an
effective and well-tolerated pharmacologic agent in treating the
mictional problems accompanying BPH.
2. Smith, H.R., et. al., 'The value of Permixon in benign prostatic
hypertrophy,' British Journal of Urology 1986; 58:36-40.
3. Tasca, A., et. al., 'Treatment of obstructive symptomatology caused
by prostatic adenoma with an extract of Serenoa repens. Double-blind
clinical study vs. placebo,' Minerva Urologica e Nefrologica 1985;
37:87-91.
4. Champault, G., Bonnard, A.M., Cauquil, J., Patel, J.C., 'Medical
treatment of prostatic adenoma. A controlled test of PA 109 vs. placebo
in 110 patients,' Ann. Urol. 1984; 18(6):407-410.
5. Crimi, A., Russo, A., 'The use of Serenoa repens extract in the
treatment of functional disturbances caused by prostate hypertrophy,'
Med. Praxis 1983; 4:47-51.
6. Sultan, C., et. al., 'Inhibition of androgen metabolism and binding
of liposterolic extract of Serenoa repens B in human foreskin
fibroblasts,' J. Steroid Biochem. 1984; 20(1):515-519.
7. El-Sheikh, M.M., Dakkak, M.R., Saddique, A., 'The effect of Permixon
on androgen receptors,' Acta Obstet Gynecol Scand 1988: 67:397-99.
8. Niederprüm, H.J., Schweikert. H.U., Zänker, K.S, 'Testosterone 5
alpha-reductase inhibition by free fatty acids from Sabal serrulata
fruits,' Phytomedicine 1994; 1:127-133.
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