Grape seed extract is a natural plant product made from the grape seed (or pip). Grape seed extract is rich in proanthocyanidins, a special class of water -soluble bioflavonoids which are highly bioavailable proantocyandins are antioxidants, 50 times more effective than Vitamin E and 20 time s more than Vitamin C. Proanthodyn is one of the few antioxidants that readily crosses the brain-blood-barrier. It is one of the most powerful free radical scavengers, and is an efficient transporter of Vitamin C, improving c's bioavailability . Grape seed extract contains esters of proanthocyanidins (especially proanthocyanidins b2-3-gallate). These proanthyocyanidin-esters have recently been described as the most active free radical neutralizers.